You have a few different options available to you for embedding matplotlib in a wxPython application 1. Embed one of the wxPython backend widgets (which subclass wx.Panel) directly and draw plots on it using matplotlib's object-oriented API. This approach is demonstrated by some of the examples embedding_in_wx*.py 2. Embed the PlotPanel from Matt Newville's `MPlot' package and draw plots on it using its plot() and oplot() methods. http://cars9.uchicago.edu/~newville/Python/MPlot/ 3. Embed the PlotPanel from Ken McIvor wxmpl module and draw plots on it using the matplotlib's object-oriented API. http://agni.phys.iit.edu/~kmcivor/wxmpl/ Each of these approachs has different benefits and drawbacks, so I encourage you to evaluate each of them and select the one that best meets your needs.