Description:

The package implements a method for normalising microarray
intensities, both between colours within array, and between arrays.
The method uses a robust variant of the maximum-likelihood estimator
for the stochastic model of microarray data described in
the references (see vignette). The model incorporates data calibration
(a.k.a. normalization), a model for the dependence of the variance on
the mean intensity, and a variance stabilizing data transformation.
Differences between transformed intensities are analogous to
"normalized log-ratios". However, in contrast to the latter, their
variance is independent of the mean, and they are usually more
sensitive and specific in detecting differential transcription.